Hospital: Survive the Night is a survival horror game in which you must hide in a security room from frightening hospital patients. You're a hospital security guard on the night shift, and you're a devout pacifist who relies solely on flashlights, CCTV, door control systems, and alarms to get by at night. Patients will try everything to get to the guard room, and it is your responsibility to stop them by closing doors in their path and distracting their attention from the hunt in any way you can.
The game is divided into five nights, and you are pursued by distraught patients in the hospital on each shift. If one of the terrifying patients approaches you, the level will be reset. You can explore the clinic and look for secrets while walking around the building between chapters. With each new shift, you'll delve deeper into the hospital's secrets, possibly discovering everything the administration decides to keep hidden from you. Throughout the hospital, there are numerous notes, medical histories, reports, and unsent letters that could reveal the hospital's secrets. If you are resourceful, you can enter all of the rooms. However, as soon as you pick up the walkie-talkie, the game enters survival mode, and the guard room is activated.